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Notably, eight taxa at the genus level were significantly abundant in the TMAO-producer group (FDR 10 M) that grouped to low producers after carnitine supplementation
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The intestinal barrier and its permeability play an important role in the pathogenesis of obesity and T2D, however, it is still unclear whether increased intestinal permeability is a cause or consequence of metabolic disease, or perhaps both ( 4.1 Chemical Barrier Antimicrobial molecules produced by the intestinal epithelium are important defense mechanisms to prevent infection and dysbiosis of commensal microbiota