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The first-round optimization led to Compound 70 , which contains a 5-methyl-1-phenyl benzimidazole moiety and exhibited an excellent increase in potency (IC 50 : 52 nM)

In the biology of hair pigmentation, after the hair follicle undergoes the 10th cycle, the ability of melanocytes to produce melanin decreases, leading to depigmented hair [225]

Glutathione plays an important role in supporting normal immune system function and helping the body manage oxidative stress

Pernicious anaemia is an autoimmune condition that causes vitamin B12 deficiency, preventing your body from producing enough healthy red blood cells

The GST catalytic center is usually divided in two distinct functional regions, a hydrophilic G-site for binding glutathione, and an adjacent hydrophobic H-site for accommodating electrophilic substrates