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30 Together, these processes reshape transcriptional landscapes, sustain CSC plasticity, rewire metabolic networks, and remodel the immune microenvironment, thereby enabling tumor cells to evade therapeutic pressure through multifactorial routes
The compounds are not interchangeable
While HDACs may more commonly erase Kl-la modifications, the removal of Kl-la compared to Kd-la might involve specific mechanisms and depend on the cross-linking of different substances within the nucleus [51]
In the study by Wang et al
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