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The disruption of these barriers has been observed in ALS patients with spinal cord or motor-cortex accumulation of proteins like fibrin and thrombin [109], reduced levels of TJ proteins, erythrocytes, haemoglobin and hemosiderin, which further cause generation of ROS, toxic to motor neurons (Fig
Histological analysis confirmed marked peribronchial and parenchymal immune infiltration following AA exposure, along with significant epithelial thickening - both of which were markedly reduced by melatonin treatment ( Figures 1D-F )
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