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While some individuals may feel liberated by reduced hunger, others may experience distress, alienation, or loss of enjoyment associated with food
These findingsoriginating from landmark trials such as EMPA-REG OUTCOME, LEADER, and SUSTAIN-6have led to substantial revisions in international guidelines from the European Society of Cardiology, American College of Cardiology, and American Heart Association, which now recommend the use of SGLT2i or GLP-1 RAs, often in conjunction with metformin
Am J Physiol Regul Integr Comp Physiol (2016) 310(10):R88595
Furthermore, there are also several reports describing episodes of pulmonary aspiration in appropriately fasted patients on GLP-1RA therapy [7, 1518]
It crosses the blood-brain barrier and supports mental clarity and focus
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