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Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap mediated sterile inflammation

Acta Pharmacol Sin 43 , 541551 (2022)

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While formal pharmacokinetic studies of GLP-1RA co-administration with these IBD drugs have not been conducted, clinicians should monitor for unexplained changes in therapeutic response, particularly during GLP-1RA initiation and dose escalation, and consider staggering oral medications when feasible

When body weight decreases substantiallyparticularly if it occurs quicklythe body may interpret this as a state of energy deficit, triggering adaptive responses that can suppress reproductive function