The number grows every month
What happens at each dose increase Regardless of which medication you take, dose increases follow a predictable pattern: Days 1 to 3 : Side effects from the higher dose may appear, particularly nausea, reduced appetite, and mild fatigue
Therefore, patients need to receive multiple injections every day, which is quite painful for diabetic patients who already need frequent needle injections, and seriously affects patient compliance
This is due to the liver taking up all the circulating FFAs, which then interfere with insulin and IGF-1 signalling (as described above) and eventually leading to hepatic steatosis
Most patients with spinal stenosis have more than one of these factors contributing at the same time, which is why a thorough evaluation by a spine specialist matters before deciding on a treatment plan