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Key Facts The Hypotensive Escalation Metric : Within six months of initiating GLP-1 therapy, the rate of documented low blood pressure events among patients on multi-drug hypertension regimens jumped from 8.7% to 10.2%

Important safety considerations include risk of pancreatitis (treatment should be discontinued if suspected), gallbladder disease, and potential worsening of diabetic retinopathy in patients with pre-existing retinopathy who experience rapid improvement in glucose control (particularly with semaglutide)

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These medications include semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound)though tirzepatide is technically a dual GIP/GLP-1 receptor agonist, not a GLP-1 RA

40 Defective IRK activity is also implicated by decreased IRS1 tyrosine phosphorylation which is consistently observed in insulin-resistant skeletal muscles