Chronic oxidative stress is linked to a wide range of diseases, including: Cardiovascular disease : ROS damage endothelial cells lining blood vessels, promoting atherosclerosis and hypertension.[9] Neurodegenerative disorders : Oxidative damage to neurons is a key driver in conditions like Alzheimers, Parkinsons and ALS.[10] Diabetes and insulin resistance : Oxidative stress impairs insulin signaling and worsens glycemic control.[10] Cancer : DNA mutations caused by free radical damage may initiate or accelerate tumor development.[11] Autoimmune conditions : Oxidative stress can trigger inflammatory pathways, contributing to immune dysregulation.[9] Even outside of these conditions, oxidative stress contributes to fatigue, slower recovery, immune suppression and premature aging at the cellular level
Metabolic optimization is always approached as a system, not a single solution
Two useful B12 books "What You Need to Know About Pernicious Anaemia and B12 Deficiency" by Martyn Hooper Martyn Hooper is the chair of PAS (Pernicious Anaemia Society)
Complications of vitamin B12 or folate deficiency anaemia Although it's uncommon, vitamin B12 or folate deficiency (with or without anaemia) can lead to complications, particularly if you have been deficient in vitamin B12 or folate for some time
Thrombin-Fibrin(ogen) Interactions, Host Defense and Risk of Thrombosis