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To account for potential dropout of up to 20%, a total of 24 subjects were planned for active treatment, and 12 subjects were planned for treatment with placebo (total for both placebo doses), leading to a total number of 36 subjects planned to start in the trial

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Other statin drugs, such as rosuvastatin and fluvastatin, can increase GSH and/or GPX in the myocardium to alleviate ISO-mediated myocardial injury [230, 231]