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Based on available Phase 2 data, both agents share a side-effect profile broadly consistent with other medicines acting on metabolic hormone pathways, though the triple-agonist mechanism of retatrutide introduces some additional considerations

Ferroptosis stand outs among other modes of cell death including apoptosis, autophagic cell death, necrosis and pyroptosis, in that it is impaired by iron chelators such as deferoxamine and ciclopirox and by lipid antioxidants such as ferrostatin-1 and a-tocopherol [13]