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In EVOKE and EVOKE+, oral semaglutide lowered several cerebrospinal-fluid markers of Alzheimers pathology, including phosphorylated tau and total tau, by up to roughly 10%, yet produced no measurable slowing of clinical decline
62 RGT075 RGT075 is a small oral GLP-1RA identified through Computer-Accelerated Rational Design (CARD) with potent G-protein-coupled cAMP signaling
Between about 50 and 56 percent of adults were female
10.1016/j.cell.2015.11.055 43 YangS.LiX.YangF.ZhaoR.PanX.LiangJ.et al (2019)
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