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As an embodiment of the present invention, the base-water-organic solvent is selected from any one of a triethylamine/water/acetonitrile system, N-diisopropylethylamine/water/acetonitrile, N-diisopropylethylamine/water/N, N-dimethylformamide and N, N-diisopropylethylamine/water/N, N-dimethylacetamide system
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Symptoms such as unexplained central weight gain, persistent fatigue, muscle weakness, easy bruising, wide purple striae, or severe hypotension warrant cortisol evaluation before attributing these to metabolic syndrome alone
Initially, the agonist properties of these ligands were compared to GLP-1 in a cAMP-sensitive luciferase reporter gene assay (CRE-luc) and revealed potency as reported previously (Fig
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