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Inhibition of incretins by DPP-4 inhibitors prolongs the half-life of incretins (GLP-1 & GIP) and is associated with increased insulin release & reduced glucagon release
This stems from rodent studies in which chronic high-dose exposure caused C-cell tumors in rats
doi: 10.1080/01616412.2025.2524741 [Epub ahead of print]
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