By synergistically activating both incretin receptors, tirzepatide has demonstrated superior efficacy in glycemic control and body weight reduction compared to selective GLP-1RAs in the landmark SURPASS (Study of Tirzepatide in Participants With Type 2 Diabetes) and SURMOUNT (Study of Tirzepatide in Participants With Obesity) clinical trial programs (Samms et al., 2022
Liu et al., 2018), with lifestyle and microbiota-based treatments specially tailored toward the specific needs of the patients could be more efficacious in the management of CKD and related complications
11(1): e0147034 Resveratrol Protects against TNF--Induced Injury in Human Umbilical Endothelial Cells through Promoting Sirtuin-1-Induced Repression of NF-KB and p38 MAPK Wei Pan, Huizhen Yu, Shujie Huang, and Pengli Zhu Anil Kumar, Editor ~ Gastroenterology
Figure 1 provides multiple pharmacotherapy options based on A1C levels, fasting or postprandial glucose control, weight loss, and adverse effects
Heres what you need to know about GLP-1 Agonists