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A previous study reported that GLP-1Rs are observed in brain regions related to energy balance and regulation of moods, such as the amygdala, hippocampus, and dorsal raphe nucleus (Merchenthaler et al., 1999)
These hallmark lesions appear years, if not decades, before symptom onset and are associated with synaptic dysfunction, progressive neuronal loss, and widespread cortical and hippocampal atrophy
These findings are in keeping with pilot clinical studies showing a beneficial effect of GLP-1 receptor agonists on binge-eating [20, 21] and confirms the need for larger clinical trials of this class of drugs in BED
* Correspondence: Huanbin Xu, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
A fund's investment in equity securities and written call options are not correlated, meaning the performance is independent of one another
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