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(off-treatment extension of a randomized trial) Podcast: The Peter Attia Drive, AMA #64: New insights on GLP-1 agonists, including lean mass and protein

doi: 10.3389/fendo.2025.1734549 Received 28 October 2025 Revised 15 December 2025 Accepted 22 December 2025 Published 15 January 2026 Volume 16 - 2025 Edited by Toshiki Otoda, Nihon University School of Medicine, Japan Reviewed by Zaiyong Zheng, Southwest Medical University, China Akash Batta, Dayanand Medical College & Hospital, India Updates Copyright 2026 Alrasheed, Mostafa, Madkhali and Khairy

No human clinical trials exist for either peptide individually or in combination

Easy measuring: At ~3.33 mg/mL, 1 unit 33 mcg total blend on a U-100 syringe 330 mcg = 10 units, 500 mcg = 15 units

Rehydration during exercise prevents the increase of homocysteine concentrations