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observations, are shown in Figure 3A

Chambers RC, Leoni P, Kaminski N, Laurent GJ, Heller RA: Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching

The tolerability profile of CsA is marked by several potentially severe adverse effects, i.e., acute or chronic nephrotoxicity, hypertension, and neurotoxicity

Notably, ERK activation is dependent on upstream PI3K signaling, indicating a hierarchical regulatory relationship between these pathways [26,27,28] (Fig