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Dosing Protocol The parallel escalation used in the REDEFINE trials, converted to U-100 units at 10 mg/mL total (5 mg/mL of each component)

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Excess weight contributes to insulin resistance, making it harder for the body to regulate blood sugar

Gastrointestinal (GI): Nausea is the most common side effect and tends to be dose-dependent

In one study, around 40% of patients that had significant vision loss experienced some improvement of their central vision over time, though there was little improvement to visual field loss