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Abdulghani AA, et al
Chronic hyponatremia exacerbates ammonia-induced brain edema in rats after portacaval anastomosis
This is a non-physiological state, but its incredibly useful for studies looking at the effects of chronic GH elevation rather than pulsatile signaling
The implications cascade through multiple metabolic pathways
There is one open-label intravenous safety pilot in two healthy adults, who received single doses of 10 mg and 20 mg with no comparator, no blinding, and short-term observation limited to vital signs, self reported symptoms and labs across two days [4]
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