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The PPAR family is composed of three members, PPAR, PPAR and PPAR, which are ubiquitously expressed in different organs and play an essential role in lipid and glucose metabolism, and inflammation

For comparing GLP-1RAs with SGLT2 inhibitors (see Fig

These are powerful drugs that act not only on appetite, but also on many organs in the body, including the brain

In addition to delaying gastric emptying, GLP-1RAs exert direct effects on the central nervous system to suppress appetite and promote weight loss [9, 11]

Stool softeners like docusate sodium have limited evidence for efficacy but may be considered as an adjunct when stools are particularly hard