Heme oxygenase (HO/HMOX1) is a cytoprotective enzyme that operates as a key rate-limiting enzyme in the process of degradation of the iron-containing molecule, heme, yielding the following by-products: CO, iron, and biliverdin (Rochette et al., 2018
This in turn drives rhythms in fatty acid oxidation through time-dependent activation of NAD + -dependent enzymes, including sirtuins and poly (ADP-ribose) polymerases 5,6
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The vitamin-like qualities of glutathione also come in handy in preventing early aging
Antioxidants (Basel, Switzerland), 10(3), 364