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X(PC) shows selectivity for residues at six amino acids within the procaspase-1 substrate sequence from P3 to P3 (Fig
Gyorkos A, Baker MH, Miutz LN, Lown DA, Jones MA, Houghton-Rahrig LD
The cleavage profile we observed for the protease was consistent with our observations of X(PC) in vitro cleavage, with procaspase-1 enriching in the top 97.8% of substrates (log 2 (fold enrichment) = 2.68) and IL-1 enriching in the top 83.5% of substrates (log 2 (fold enrichment) = 1.05
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