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Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) Total RNA was isolated from K1, MDA-T32, MDA-T68, and HThF cells using RNEasy Plus kit (Qiagen, MD)

The principal neurological function regulated by GLP-1RA could be summarized as follows ( Figure 2 ): (1) GLP-1RA liraglutide and exendin-4 effectively inhibited neuronal apoptosis ( Figure 2 4 GLP-1RA reduced the risk of stroke in T2D patients clinically As a new type of hypoglycemic drug, GLP-RAs are currently mainly used in clinical practice to evaluate the prognosis of various complications in T2D patients, such as stroke, kidney injury, fatty liver, and cardiovascular disease (43)

Nephroprotective properties of the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonists