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529 Tramadol: should be used cautiously due to similar concerns regarding dependence and side effects
A randomized controlled trial by Miller, Wagner, and colleagues published in the Archives of Facial Plastic Surgery in 2006 evaluated topical copper tripeptide complex on CO2 laser-resurfaced skin in 13 patients and found no statistically significant differences between groups for resolution of erythema, wrinkles, or overall skin quality on objective assessment, although subjective patient-reported skin quality favored the GHK-Cu side (p = 0.04)
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While they are normally the result of stress, various environmental factors such as smoke and pollutants can also trigger their formation
Avoid or minimize strictly
Gliozzi M, Walker R, Muscoli S, et al
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