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Some medical conditions that increase the size of the spleen can lead to splenic sequestration, a medical condition where platelets are sequestered in the spleen leading to thrombocytopenia

For example, amphetamines were once widely prescribed for weight loss, until they were linked to high blood pressure, heart complications, anxiety, and aggression

(July 1982)

Indeed, in rodent studies, GLP-1/GIP/GCG triple agonists produced greater WL than mono- or GLP-1/GIP dual agonists [22], suggesting potential additional metabolic benefits ( Fig