Overall, these findings are complementary to results in a companion article 57 , in which the body-weight-reducing and food-intake-reducing effects of GIPR antagonism are disrupted in mice with global loss of either Gipr or Glp1r but preserved in mice with loss of Gipr in either GABAergic or peripheral neurons
Even better, in the open-label extension out to 56 weeks, there was no clear plateau - still around 16.2% total loss on average
Carvalheira AA, Pereira NM, Maroco J, Forjaz V
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