A few possible relevant articles were excluded due to language issues
It functions as a water-soluble antioxidant
Lilly's oral GLP-1, orforglipron, demonstrated superior glycemic control in two successful Phase 3 trials, reconfirming its potential as a foundational treatment in type 2 diabetes In ACHIEVE-2, orforglipron lowered A1C by up to 1.7% compared to 0.8% with dapagliflozin, meeting the primary endpoint In ACHIEVE-5, orforglipron lowered A1C by an additional 2.1% when taken with insulin glargine, meeting the primary endpoint 1,2,3 "Orforglipron has now demonstrated superiority over two active comparators in clinical trials for type 2 diabetes," said In both trials, the overall safety and tolerability profile of orforglipron, as well as treatment discontinuation rates, were consistent with previous studies
Similar benefits may be plausible in T1D, but supporting data are limited
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