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On average, body weight dropped 13.7 percent in the group given semaglutide compared to 3.2 percent given placebos, while the reported pain scores dropped 41.7 points and 27.5 points respectively (the pain scale used runs from 0 to 96)

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When semaglutide is introduced after gastric sleeve surgery, it provides supraphysiologic GLP-1 receptor activation that exceeds the endogenous incretin response generated by the altered anatomy

10.1016/0024-3205(93)90589-u 70 SikiricP.RucmanR.TurkovicB.SeverM.KlicekR.RadicB.et al (2018)