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1068 Metformin also reduces insulin-like growth factor (IGF) signaling pathway activity, decreases glucose absorption, and promotes glucose breakdown, thus reducing energy supply and growth of cancer cells

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Administer an initial dose of 500 mg/m, dissolved in 100 ml of normal saline, via intravenous administration, followed by a maintenance dose of 300600 mg daily via intramuscular injection

Neurosci Lett 133: 1114