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In addition to their anti-inflammatory effects, these compounds have inhibitory effects on the following pathways: inflammasome (NLRP3), Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, endothelial cell vascular cell adhesion molecule-1 (VCAM-1) or intercellular adhesion molecule-1 (ICAM-1), matrix metalloproteinases involved in remodelling and metastasis (MMP 2, MMP 9), and chronic cycloxogenase derived prostaglandins that promote angiogenesis and immunosuppression (182)
Nanoparticles of 2-deoxy-D-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment
Nefrologia 40:664671 Bliard Veillard R PharmD, Pinto B PharmD (2018) DPP-IV Inhibitors
BPC-157 and similar compounds tested in horses with generally positive results
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