Because copper itself has a narrow physiological range, protocols involving repeated or high-frequency application in animal models often include copper-load monitoring alongside the primary remodeling endpoints, to rule out confounding from excess trace-mineral exposure rather than peptide-specific signaling
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In addition, it may have beneficial effects by reducing oxidative stress, which is considered one of the etiologies of ASD [86]
2014;6(221):221ra15
Future Potential : The robust pipeline of increasingly effective agents, combined with emerging oral formulations and potential cost reduction strategies, suggests that current limitations may be surmountable with continued innovation and policy development