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The human studies available show no increased rate of major birth defects from first-trimester GLP-1 exposure
The key findings relevant to this question: No clinically relevant drug-metabolizing enzyme-mediated interactions have been reported for GLP-1 agonists Some transporters (OATP1B1/3, OAT3) showed inhibition with GLP-1 agonist treatment in vitro Significant changes in oral contraceptive and levothyroxine absorption were documented with tirzepatide and oral semaglutide GLP-1 agonists delay gastric emptying, which can alter absorption of co-administered oral medications Critically, no published study has examined the drug-drug interaction profile of two injectable GLP-1 agonists administered concurrently
Educational background: The semaglutide molecule was originally developed for type 2 diabetes and is sold under the brand names Ozempic (for diabetes) and Wegovy (used for chronic weight management)
