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4.8 Electrolytes (Potassium, Sodium) Physiological Role Electrolytes regulate: Fluid balance Cardiac conduction Neuromuscular function Why GLP-1 Therapy May Influence Electrolytes Electrolyte imbalance may occur secondary to: Persistent vomiting Diarrhoea Reduced fluid intake Rapid weight loss This is most relevant during dose escalation or in patients with ongoing GI symptoms
According to NICE guidance (NG28), the continuation of GLP-1 receptor agonist therapy in type 2 diabetes should be assessed after six months, with treatment continued only if there is a reduction in HbA1c of at least 11 mmol/mol (1%) and, where applicable, a weight loss of at least 3% of initial body weight
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These updates reflect ongoing shifts and advancements within the pharmaceutical landscape as companies navigate innovation, competition, and strategic investments
