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The extended amygdala also plays an important role in alcohol reinforcement and reinstatement, so NPY may affect other alcohol-related behaviors through its actions in the amygdala
Phase II data (NEJM, 2023) showed up to 24.2% mean body weight reduction with Retatrutide at 12mg weekly over 48 weeks, compared to approximately 21% with Tirzepatide at 15mg in the SURMOUNT trials over comparable periods
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