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Machine learning algorithms trained on existing GLP-1 receptor modulators likely helped establish correlations between structural features and functional outcomes, guiding medicinal chemistry efforts toward the most promising compounds

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Starting conservatively and adjusting based on individual response remains the best approach to minimize any negative effects while maximizing benefits

Adrenal tumours typically require surgical adrenalectomy, whilst ectopic ACTH-secreting tumours necessitate identification and removal of the primary malignancy when feasible