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In other words, it should only be used as a vehicle for other drugs, not as fluid replacement

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Packer 2025 in NEJM (PMID 39555826) reported on heart failure with preserved ejection fraction (SUMMIT), with tirzepatide producing improvements in patient-reported symptom burden and quality-of-life scores

Over time, these proteins have a compounding effect on the body that contributes to and worsens these conditions