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doi: 10.1097/SLA.0000000000001691 65 XuYTangYLuJZhangWZhuYZhangSet al

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Abbreviations ALP: alkaline phosphatase ALT: alanine aminotransferase AST: aspartate aminotransferase CKD: chronic kidney disease GGT: gamma glutamyl transpeptidase HGF: hepatocyte growth factor HPP: hypophosphatasia NSHA: nonspherocytic hemolytic anemia PLP: pyridoxal 5-phosphate TNSALP: tissue-nonspecific alkaline phosphatase Declarations Acknowledgement The support of the Herman Lopata Chair in Hepatitis Research is gratefully acknowledged

If the blood clot breaks off, it can travel to the lungs, resulting in a potentially life-threatening pulmonary embolism

Water-soluble vitamins : B-vitamins are primarily water-soluble, limiting their ability to cross the stratum corneum without specialised delivery systems