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Summary: Excessive vitamin B12 intake rarely causes toxicity, but very high levels from supplements or injections may be associated with skin reactions such as acne-like eruptions, though serious adverse effects remain exceptionally uncommon

In the pituitary gland, it co-localizes with numerous peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotropic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH), and melanin-concentrating hormone (MCH)

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