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Pramlintide was not clastogenic in the in vivo mouse micronucleus test or in the chromosomal aberration assay utilizing Chinese hamster ovary cells

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We observed that brief pretreatment with GLP-1(2836) versus the scrambled control increased glycolysis by 36% (extracellular acidification rate [ECAR]: 14.5 1.6 vs

GLP1-E2 also exerted the most pronounced downregulatory effect on disallowed genes and MHC-related transcripts, the latter aligning with reduced insulitis observed even with monotherapy