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For instance, in NSCLC, treatment with first- and second-generation EGFR tyrosine kinase inhibitors (TKIs) often leads to the development of the EGFR T790M mutation, while third-generation inhibitors subsequently select for the C797S mutation, both of which confer resistance

This is the fundamental challenge Integrative Peptides must address

PMID 32310424

It remains to be seen how common is NPC1 upregulation is cancers that use macropinocytosis for cholesterol uptake, and when the first clinically approved macropinocytosis inhibitors will be developed