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Phase I metabolism also involves cytochrome P450 (CYP) enzymes, particularly CYP3A4, which is the most prevalent hepatic enzyme and plays a key role in metabolizing dietary phytochemicals like curcumin (109111)

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On one hand, neutrophils significantly contribute to immune dysregulation and tissue damage through the formation of neutrophil extracellular traps (NETs), which are rich in decondensed nucleic acids and expel chromatin that can trigger specific autoreactive immune responses to nucleic acid antigens (79, 80)

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