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Medical researcher Kamyar Kalantar-Zadeh from the Harold Simmons Center for Kidney Disease Research and Epidemiology reports that there is a 28% death risk for chronic kidney disease patients with significant fluid retention, whereas with the minimal fluid retention [between 0.5 and 1.0 kg], there was 26% higher survival chance

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Potential mechanisms include improvements in blood pressure, lipid profiles, body weight, inflammation, and endothelial function as well as direct cardioprotective effects on the cardiac muscle and vasculature [41]

Nat Rev Nephrol 13 , 605628 (2017)

In human studies conducted to date, no increased risk of thyroid cancer has been established, but the warning remains in place given the rodent data and the fact that long-term human data is still accumulating