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46 S-ADENOSYL- L-METHIONINE Hepatic GSH concentrations have been restored to nearly normal in liver biopsies of patients with cirrhosis following long-term oral SAM administration

It has not progressed to extensive clinical trials, meaning its human safety and efficacy profile is not established it remains strictly a preclinical research compound

However, these preclinical findings do not establish safety for use during human pregnancy, as species differences in placental transfer and fetal metabolism may exist

V.PatelS

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimers disease