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These compounds activate the Nrf2 pathway, a cellular signaling system that upregulates expression of genes involved in antioxidant production including glutathione synthesis enzymes

A 2020 human clinical trial found that cosmetics containing Artemisia Annua Extract increased stratum corneum hydration and reduced transepidermal water loss while also calming redness and inflammation over four weeks of use

For routine antioxidant or longevity support, bypassing digestion does not automatically justify bypassing caution

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