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These advances have led to rapid succession to the approval of the anti-PD-1 antibodies pembrolizumab and nivolumab (both in 2014), followed by the anti-PD-L1 antibodies atezolizumab (in 2016) and durvalumab (in 2017), as second-line therapies for advanced melanoma and metastatic colorectal cancer (mCRC) [37]
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