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Lean C57BL/6J mice and genetically obese (ob/ob) mice, all 12 weeks old, were divided into three treatment groups including: saline control, AOD9604 at a dose of 250 g/kg/day, and hGH at a dose of 1 mg/kg/day, with each group consisting of six mice

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Connecting AD and DS is A42, which plays an important role in the pathogenesis of AD and may also affect the cognitive function seen in DS 12,13

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Their trials though appeared promising but could not be extrapolated for humans, showing the urgency for novel models to test nanobased ALS therapies (Figure 3)