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Its defining modification is a trans -3-hexenoyl group attached to the N-terminal tyrosine, a chemical change designed to protect the peptide from rapid cleavage by dipeptidyl peptidase-4 (DPP-4), the enzyme that quickly inactivates native GHRH
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This 10,000mcg configuration provides a highly stable biochemical tool for investigating dual calcitonin and amylin receptor agonism, non-glucocentric satiety pathways, and synergistic incretin combinations
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