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Given that L-carnitine uptake into skeletal muscle occurs slowly and is influenced by insulin availability and training status, chronic exposure to elevated plasma LC levels may eventually reduce the responsiveness of transport mechanisms or alter carnitine homeostasis
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The early divergence of the MACE occurrence curves between the SEMA and placebo groups23 suggests that SEMA may have been directly involved in the SELECT study results through its effects on angiogenesis, reduction of oxidative stress and inflammation, and anti-atherogenic actions derived from GLP-1R activation that promote endothelial function and cell survival7 (Fig
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