Validation of XOI-based ULT effects on xanthine and purine metabolism by serum metabolomic profiling
These compounds are classified as NDBs and have unique physical, chemical, and mechanical properties, which are exploited in biomedical applications
In these cases with the committed renal flow of the blood as evidenced by the low flow of urine, the transfusion is the ideal in order to eliminate the damaged red cells that block the microcirculation and can also avoid the renal complication
Before human translation, essential parameters to define: optimal dosing, infusion/administration route, frequency, biomarkers to monitor (senescent cell burden, inflammatory cytokines, organ function), long-term follow-up for adverse outcomes (especially tumour risk)
Never share a multi-dose vial between different patients